Study challenges assumptions over how l-oligonucleotides behave in living systems

A D-RNA structure reflacted as an L-RNA structure in a mirror

Source: Adapted from Chen-Hsu Yu and Jonathan T. Sczepanski, Chemical Science, 2023

L-oligonucleotides are potentially cytotoxic but some could have unexpected therapeutic benefits

Researchers have uncovered that L-oligonucleotides, previously thought to be non-toxic, could actually be harmful to cells. This discovery, whilst still needing further investigation, could provide a new avenue for pharmaceutical research.