Crispr first as disease-causing mutation edited in human embryos

Illustration of surgically editing a strand of DNA

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Faulty gene that causes serious heart condition corrected

The Crispr–Cas9 genome editing tool has been used to correct a disease-causing mutation in human embryos for the first time. Hypertrophic cardiomyopathy (HCM) is a serious heart condition caused by a single genetic mutation that affects about 0.2% of people. Although it can be treated with medication the underlying genetic cause currently cannot be cured and those who carry the faulty gene have a 50% chance of passing it to their children.