Overreliance on cryocooled protein structures may compromise computational structure-based drug design

By Ellis Wilde2021-09-07T08:13:00

Source: © Marcus Fischer/St Jude Children's Research Hospital

Scientists behind first of its kind study encourage more researchers to analyse protein structures at room temperature

Temperature can severely influence the conformational state and ligand binding properties of a protein, new research shows. Consequently, computational modelling based solely on cryogenic structural data may produce misleading results.