Derek Lowe – Page 5

  • 0616CWPipeline
    Opinion

    Let's see that again

    2016-05-27T00:00:00Z

    Has chemistry evaded the reproducibility crises affecting other branches of science? Or is it just a question of scale, asks Derek Lowe

  • Valeant stocks on a monitor
    Opinion

    Valeant in defeat

    2016-05-09T00:00:00Z

    Derek Lowe looks at what can be learned from a drug company’s downfall

  • 0416CW_In-the-pipeline_300tb
    Opinion

    Throwing things over the fence

    2016-04-04T00:00:00Z

    Saying ‘That’s someone else’s problem’ is asking for trouble, says Derek Lowe

  • CW0316_Pipeline_630m
    Opinion

    Drugs don’t grow on trees

    2016-03-15T00:00:00Z

    The trope of companies profiteering from academic discoveries doesn’t bear much scrutiny, says Derek Lowe

  • 0216CW_Pipeline_630m
    Opinion

    Pride comes before a fall

    2016-02-02T00:00:00Z

    In labs it’s important not to let familiarity breed complacency, says Derek Lowe

  • 0116CW_Pipeline_630m
    Opinion

    The sack race

    2015-12-23T00:00:00Z

    Looking to get fired? Derek Lowe offers some hot tips for a quick exit

  • dictionary
    Opinion

    Emerging from Babel

    2015-11-26T00:00:00Z

    Will English ever lose its place as the lingua franca of chemistry, asks Derek Lowe

  • Martin Shkreli
    Opinion

    What the market will bear?

    2015-09-30T00:00:00Z

    Martin Shkreli’s monopolising model poses some uncomfortable questions for the pharma industry, says Derek Lowe

  • Hot sauce
    Opinion

    Spice up your compounds

    2015-09-25T00:00:00Z

    An occasional foray into uncharted territory is the hot sauce of medicinal chemistry, says Derek Lowe

  • CW0915_Pipeline_630m
    Opinion

    A risky business

    2015-08-28T00:00:00Z

    Graduate research is likely the most risky time of a chemist’s career, says Derek Lowe

  • 0815CW_Pipeline_630m
    Opinion

    A precision instrument?

    2015-07-30T00:00:00Z

    Chemists and biologists have different expectations when it comes to data, says Derek Lowe

  • Arrows missing a target
    Opinion

    Missing the target

    2015-06-23T00:00:00Z

    There are plenty of things that small molecule drugs can’t touch, says Derek Lowe, and it’s not for want of trying

  • 0615CW_Pipeline_630m
    Opinion

    Magic molecule modifiers

    2015-05-29T00:00:00Z

    Late stage functionalisation can seem supernaturally powerful, says Derek Lowe – if you’ve got the nerve to try it

  • CW0515_Pipeline_630m
    Opinion

    Missing mathematics?

    2015-04-29T00:00:00Z

    While you may not need differential calculus every day, mathematics is the basis of scientific thinking, says Derek Lowe

  • CW0415_Pipeline_630m
    Opinion

    Analogues by catalogue

    2015-03-24T00:00:00Z

    Buying in screening compounds directly feels like cutting out the synthetic chemist middleman, says Derek Lowe

  • Computer modelling computer screen
    Opinion

    Tantalising technology

    2015-02-20T00:00:00Z

    Computer-assisted drug design always looks like it’s just about to work, says Derek Lowe, but the reality is complicated

  • 0215CW_Pipeline_300m
    Opinion

    The smell of success

    2015-02-11T00:00:00Z

    Laboratory aromas conjure memories and emotions from elation to a sudden need to vomit, says Derek Lowe

  • CW0115_Pipeline_630m
    Opinion

    Ignorance is no defence

    2015-01-14T00:00:00Z

    In a chemistry lab, what you don’t know really can hurt you, says Derek Lowe

  • CW1214_InthePipeline_630m
    Opinion

    Progress at the pace of the slowest

    2014-12-01T00:00:00Z

    Chemistry is rarely the rate-limiting process in getting a drug to market, says Derek Lowe

  • CW1114_In-the-Pipeline_Fig1_630m
    Opinion

    Chemical space is big. Really big

    2014-10-28T00:00:00Z

    You think it’s a long way to the back of your screening libraries? That’s peanuts to chemical space, says Derek Lowe